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We used milk EXOs to separately encapsulate four weak lipophilic drugs (Log P ≤ 1, Fig. 2) and four strong lipophilic drugs (log P > 1, Fig. 2) with various molecular weights. As indicated in Fig. 3, the loading efficiencies of EXOs were high for all four hydrophilic drugs with different molecular weights, with the highest loading efficiency ranging from 33.38% to 64.77%. However, the loading efficiencies of EXOs for hydrophobic drugs were significantly reduced, and the highest loading efficiency of the four drugs was only between 13.37% and 21.6% (Fig. 4). In conclusion, the lipophilicity of drugs is an important factor affecting the drug loading efficiency of EXOs, and the loading efficiencies of EXOs for hydrophilic drugs is significantly higher than that for hydrophobic drugs.